Triflic acid, CAS: 1493-13-6

Key Applications:

1. Organic Synthesis & Reaction Activation

• Protonates weakly basic substrates and hydrocarbons, enabling otherwise inaccessible transformations.
• Facilitates Friedel–Crafts alkylation and acylation, esterification, dehydration, and rearrangement reactions.
• Used to generate highly reactive intermediates, including carbocations and sulfonate esters.
• Serves as a strong acid catalyst in protecting group chemistry, including tert‑butyl and silyl group manipulations.

2. Catalysis in Industrial & Fine Chemical Manufacturing

• Acts as a robust, non‑oxidizing acid catalyst in pharmaceutical synthesis, improving yields and selectivity in key steps.
• Supports polymerization reactions, including cationic polymerizations requiring strong proton donors.
• Enables high‑efficiency catalytic cycles in petrochemical upgrading and specialty chemical production.

3. Electrolytes, Salts & Advanced Materials

• Serves as a precursor to triflate salts, widely used in battery electrolytes, ionic liquids, and high‑performance materials.
• Used in the synthesis of metal triflates, which function as Lewis acid catalysts in green chemistry.
• Supports development of electronic materials, including etching and doping processes in semiconductor fabrication.

4. Environmental & Green Chemistry Applications

• Enables cleaner catalytic pathways due to its stability and low nucleophilicity, reducing by‑product formation.
• Plays a role in designing recyclable catalytic systems and solvent‑free reaction conditions.

5. Pharmaceutical & Biochemical Applications

• Used in the synthesis of active pharmaceutical ingredients (APIs) requiring strong, selective protonation steps.
• Supports formation of complex heterocycles and functionalized aromatic systems.

6. Specialty & Niche Applications

• Functions in surface modification, fluorinated material synthesis, and precision etching in electronics manufacturing.
• Employed in mechanistic studies involving superacid‑stabilized intermediates.

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