Methyl triflate, CAS: 333-27-7

Key Applications:

1. Organic Synthesis & Methylation Chemistry

• High‑reactivity methylating agent for oxygen, nitrogen, sulfur, and carbon nucleophiles.
• Enables O‑methylation of alcohols and phenols, N‑methylation of amines and heterocycles, and S‑methylation of thiols.
• Frequently used when milder methylating agents (e.g., dimethyl sulfate, methyl iodide) are insufficient.

2. Pharmaceutical & Fine Chemical Intermediates

• Supports the synthesis of API intermediates, heterocycles, and alkaloid derivatives.
• Used in late‑stage functionalization where high selectivity and strong electrophilicity are required.
• Plays a role in constructing quaternary ammonium salts and cationic building blocks.

3. Catalyst Activation & Salt Formation

• Converts neutral ligands or precatalysts into cationic, highly active catalytic species.
• Commonly used to generate cationic metal complexes in:
  • C–H activation
  • Olefin polymerization
  • Cross‑coupling catalysis

4. Materials Science & Polymer Chemistry

• Methylates functional groups in specialty polymers, enabling:
  • Charge‑transport tuning
  • Ion‑exchange membrane modification
  • Surface functionalization for advanced materials

5. Ionic Liquid & Salt Synthesis

• Key reagent for preparing methylated cations, including:
  • Quaternary ammonium salts
  • Phosphonium salts
  • Sulfonium salts
• Supports the development of task‑specific ionic liquids with tailored polarity and conductivity.

6. Protecting Group Chemistry

• Used to install methyl protecting groups on nucleophilic sites.
• Offers high yields and clean reaction profiles, especially in complex molecule synthesis.

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