Imidazole, CAS: 288-32-4

Key Applications:

Catalysis and Synthesis

• Widely used as a nucleophilic catalyst and base in organic synthesis, particularly for acylation, phosphorylation, and carbodiimide-mediated coupling reactions.
• Serves as a precursor for synthesizing imidazolium-based ionic liquids, metal–organic frameworks (MOFs), and heterocyclic intermediates.
• Functions as a ligand in coordination chemistry, forming stable complexes with transition metals for catalytic and mechanistic studies.

Polymer and Materials Chemistry

• Acts as a curing accelerator and catalyst in epoxy resin systems, improving crosslinking efficiency and thermal performance.
• Used in polyurethane and polycarbonate synthesis as a chain extender or catalyst.
• Contributes to the formation of conductive polymers and advanced materials through imidazole-functionalized monomers.

Biochemistry and Life Sciences

• Commonly employed as an elution agent in immobilized metal affinity chromatography (IMAC) for purification of His-tagged proteins.
• Serves as a buffer component due to its pKa near physiological pH, supporting enzyme assays and biochemical workflows.
• Used in studies of enzyme mechanisms, proton transfer, and histidine-mimicking systems.

Pharmaceutical and Medicinal Chemistry

• Acts as a building block for antifungal, anticancer, and anti-inflammatory drug candidates.
• Incorporated into heterocyclic scaffolds to modulate bioavailability, binding affinity, and metabolic stability.

Analytical and Environmental Applications

• Functions as a derivatization reagent in chromatography and mass spectrometry.
• Utilized in corrosion inhibition studies for metals, especially copper and steel.
• Supports CO₂ capture research through imidazole-based sorbents and functionalized materials.

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