1-Methylimidazole, CAS: 616-47-7

Key Applications:

Thermodynamics and Solution Chemistry

• Serves as a model heterocycle for studying protonation equilibria, pKa shifts, and temperature‑dependent acid–base behavior in aqueous media.
• Used in thermodynamic investigations of hydrogen‑bonding networks, solvation energies, and enthalpy/entropy contributions in mixed solvent systems.
• Supports research on ion–dipole interactions and activity coefficients, enabling calibration of predictive models for electrolyte and non‑electrolyte solutions.
• Functions as a benchmark compound for evaluating temperature‑dependent partitioning, vapor–liquid equilibria, and aqueous–organic phase behavior.

Catalysis and Synthesis

• Acts as a mild, selective nucleophilic catalyst in acylation, esterification, and carbonyl‑activation reactions.
• Used as a base and ligand in organometallic transformations, including transition‑metal‑mediated coupling and activation pathways.
• Supports synthesis of ionic liquids, imidazolium salts, and functionalized heterocycles through N‑alkylation and quaternization.

Polymer and Materials Chemistry

• Employed as a curing accelerator in epoxy and polyurethane systems, improving crosslinking kinetics and thermal stability.
• Used as a precursor or modifier in designing imidazole‑functional polymers with tunable hydrophilicity and ion‑transport properties.
• Contributes to studies of polymer–solvent interactions, particularly in water‑rich environments where imidazole–water hydrogen bonding influences swelling and diffusion.

Analytical and Biochemical Applications

• Serves as a reference compound for NMR, UV‑Vis, and conductivity studies involving heterocyclic bases in aqueous solutions.
• Used in biochemical buffer development where imidazole‑based proton donors/acceptors are required for pH‑sensitive assays.
• Supports mechanistic studies of enzyme‑mimetic catalysis, especially those involving histidine‑like proton shuttling.

Electrochemistry and Energy

• Investigated as a proton‑conducting additive in aqueous and mixed‑solvent electrolytes.
• Used to probe electrode interfacial thermodynamics, including adsorption, charge transfer, and solvation structure.
• Contributes to formulation studies for aqueous batteries, supercapacitors, and fuel‑cell membranes where imidazole–water interactions influence conductivity.

Please contact us if you want to learn more or need assistance with your order.